Glioblastoma Research Organization

Raising awareness and funds for new global, cutting-edge research to find a cure for Glioblastoma.

HOUSTON (PRWEB)
August 11, 2020

Funded by the Glioblastoma Research Organization, the Laboratory of Dr. Steven Millward at MD Anderson Cancer Center has launched the The Lee Project which focuses on directed evolution of vectors for the treatment of GBM.

Glioblastoma remains one of the most lethal cancers, due in large part to its invasiveness and dissemination throughout normal brain tissue. As a result, surgical resection and targeted radiotherapy are extremely challenging in GBM patients. While advances in chemotherapy have dramatically improved patient outcomes in non-CNS tumors, GBM remains refractory to most chemotherapeutics. This is due, in large part, to the difficulties in building up sufficient concentrations of drug in the tumor without causing substantial damage to healthy tissue throughout the body. One of the obstacles to delivering chemotherapeutics into the brain is the blood-brain barrier (BBB). This tightly sealed vasculature, which normally protects the brain from toxins and infection, can be co-opted by the tumor to effectively shut out chemotherapeutic agents. We propose to evolve small cyclic peptides that readily cross the BBB using a technique called SUPR peptide mRNA Display. We hypothesize that by attaching these BBB-penetrating peptides to chemotherapeutics, we can selectively deliver high concentrations of these drugs to the GBM tumor with minimal toxicity to the rest of the body. If successful, our approach will provide a mechanism to deploy a wide range of otherwise non-BBB penetrant chemotherapeutics in GBM patients.

To carry out these directed evolution experiments, we synthesized a large library of over 100 billion cyclic peptides which was placed on one side of an artificial BBB. We then waited for a brief period of time and retrieved peptides that migrated across the BBB to the other side. These peptides were then amplified (copied) which formed the basis of a new library that was enriched for peptides that could cross the BBB. We repeated the process five times and then identified the sequence (structure) of the peptides that managed to cross the barrier each time. We synthesized (made) five of these peptides and found that one of them indeed could cross the BBB barrier with high efficiency. We are now in the process of labeling this peptide with a radioisotope which will allow us to use PET imaging to “see” if the peptide can cross the BBB in mice. If we observe brain penetration in mice, we will replace the radioisotope with chemotherapeutics to determine if their effect on brain tumors can be enhanced by increasing their BBB permeability.

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SAN DIEGO (PRWEB)
August 11, 2020

Extraordinary Conceptions, a premier surrogacy and egg donation agency, is proud to announce the opening of its Mexico office to help even more intended parents realize their dream of starting a family. The Puerto Vallarta location is the agency’s most cost-effective option in North America. It is part of Extraordinary Conceptions’ commitment to providing affordable options to clients who may be dealing with financial challenges during these unprecedented times.

Based in San Diego, Extraordinary Conceptions has helped clients from around the world find their ideal egg donors and gestational carriers since 2005. During that time, the agency has built an excellent reputation for guiding future families through egg donation or surrogacy with warmth and compassion. As with all Extraordinary Conceptions locations, the Mexico office will be staffed with a knowledgeable, empathetic team. It has partnered with two of the top IVF clinics in the country. The goal is to give all intended parents a comfortable, supportive fertility journey.

“We are so excited to be able to offer choices in Mexico to our intended parents,” says Mario Caballero, CEO of Extraordinary Conceptions. “We have gone to great lengths to create surrogacy and egg donation programs with proven IVF centers and reproductive attorneys for your safety and assurance. And the best part is that all U.S. laws and our strict protocol will be followed in conjunction with the legalities in Mexico.”

Applications for future parents, egg donors and surrogates are available on the Extraordinary Conceptions website. For more information, or to learn more about the Mexico location,

visit https://www.extraconceptions.com.

About Extraordinary Conceptions: Extraordinary Conceptions is a premier agency that’s helped thousands of Intended Parents achieve their dreams of building a family through surrogacy and egg donation. As the leading international agency, Extraordinary Conceptions guides clients to discover their perfect egg donor and Gestational Carrier to help fulfill their dreams of parenthood. Extraordinary Conceptions’ commitment, skills and compassion are unparalleled by other agencies in the fertility field. For more information, visit https://www.extraconceptions.com.

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ARLINGTON, Va. (PRWEB)
August 11, 2020

HUNGRY Marketplace Inc., the celebrity-backed platform connecting top chefs with people looking for local chef-made meals, today announced it has reached a major milestone in the company’s efforts to feed those serving on the frontlines in the fight against COVID-19.

In partnership with Virginia-based nonprofit Pivotal Moments and other generous donors, HUNGRY has helped raise more than $115,000 to provide healthcare workers, first responders, EMTs, paramedics and their families with nutritious, chef-made meals.

“We’re proud to feed the brave men and women who’ve been working so hard to keep our communities safe and healthy,” said Jeff Grass, HUNGRY CEO. “Thanks to the generosity of hundreds of donors and our partners, we’ve been able to do our part in giving back to these frontline heroes.”

In March, HUNGRY began leveraging its proprietary technology to get food into the hands of essential workers and at-risk groups in major U.S. cities at tremendous scale. Since then, HUNGRY has facilitated meal donations on behalf of several notable personalities, including Kevin Hart, Todd Gurley and Bobby Wagner, as well as celebrity chefs Tom Colicchio and Ming Tsai.

In addition to providing free meals as a result of outside donations, HUNGRY has also been donating four meals for every one meal sold via its HUNGRY@Home meal delivery service – an online, direct-to-consumer delivery program – and one meal for every two catered meals sold via its chef-to-business catering program.

“Finding ways to adapt our business model and tools to help frontline and essential workers during this time has been a top priority of ours,” shares Grass. “We will continue to deliver healthy, high-quality food to healthcare heroes throughout the country as long as there is a need.”

Anyone can make a tax-deductible donation via Pivotal Moments to help feed deserving healthcare heroes as part of HUNGRY’s initiative.

For more information, visit tryhungry.com/home or pivotalmoments.org/food.

About HUNGRY:

HUNGRY was founded by serial entrepreneurs Eman Pahlavani, Shy Pahlevani and Jeff Grass, as a revolutionary technology connecting independent chefs with the $60 billion business and events catering market. HUNGRY is committed to improving the communities it serves. Through its ‘Fight Against Hunger’ program, HUNGRY donates one meal to those in need for every two purchased. Additionally, its ‘WeRecycle’ program promotes environmental waste reduction by offering biodegradable plates and cutlery with its delivered meals. HUNGRY is headquartered in Washington, D.C. and has rapidly growing operations in Philadelphia, Atlanta, Boston, New York City, Austin and Dallas. For more information, visit tryhungry.com.

About HUNGRY@Home:

HUNGRY@Home is a direct-to-door food delivery service available in the cities HUNGRY already serves. The safe, family-style food delivery concept features chef crafted menu items that incorporate locally sourced ingredients and provide up to eight individual servings of delicious, good-for-you food in every meal. For every one meal sold via HUNGRY@Home, HUNGRY donates four meals to help someone in need. For more information and to place an order, visit http://www.TryHungry.com/Home.

About Pivotal Moments:

Pivotal Moments is a 501 (c)(3) charity who develops, supports, and promotes entertainment and educational programs to help people become champions for mental wellness. Through individual and company donations we create content and programs, and support others who are committed to increase awareness, education, and advocacy for mental wellness in our communities.

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SEATTLE (PRWEB)
August 11, 2020

Cloudticity, a next-gen managed services, compliance, and security partner for healthcare companies, has seen its business momentum accelerate greatly in the first half of 2020. Addressing key needs that have emerged during the COVID-19 pandemic, Cloudticity has seen its year-over-year net revenues grow 40% and its customer base increase by 23%. Focused exclusively on helping organizations harness the power of the cloud to radically reshape healthcare, Cloudticity launched several new product solutions and garnered multiple industry honors thus far in 2020.

“The COVID-19 crisis is more impactful than anyone imagined in driving demand for real-time actionable intelligence from disparate healthcare data sources,” said Cloudticity founder and CEO Gerry Miller. “In our effort to make the world a healthier place, we created a purpose-built next-generation data platform—Cloudticity Healthcare DataHub™—that has unprecedented automation capabilities. Using our platform, states, counties, municipalities, healthcare information exchanges, hospital groups, and other organizations can quickly and cost-efficiently monitor, aggregate, measure, analyze, and report on this continuously evolving crisis. They can visualize clinical data in real time to see emerging trends/changes, intelligently manage their ventilator inventories and ICU beds, and uncover deeper correlations with machine learning—such as comorbidities, demographics, social determinants, etc.—that often influence COVID-19 outcomes.”

Cloudticity has built some of the largest healthcare systems on Amazon Web Services (AWS), including the first patient portal, the first health information exchange (HIE), and the first FISMA high deployment on AWS GovCloud. In 2020, the company partnered with AWS on a critical state deployment to flatten the coronavirus curve. The case study can be heard here: Bringing it all Together, Real-time Clinical Data Consolidation for the Covid-19 Pandemic and Beyond.

2020 Healthcare Products and Solutions

Select Industry Awards and Accolades

To learn more about Cloudticity’s platform, read How Cloudticity Uses AIOps to Reinvent Managed Services or schedule a consultation.

About Cloudticity

Founded in 2011, Cloudticity helps healthcare organizations reshape healthcare by unlocking the full potential of the cloud. Through groundbreaking automation and world-class cloud expertise, Cloudticity solutions empower healthcare organizations to create and scale the industry’s next breakthrough solutions, resulting in more holistic healthcare, improved patient outcomes, and a healthier, happier world. Distinguished for building some of the earliest healthcare systems on AWS, fast-growing Cloudticity appears on multiple lists of top managed services providers (MSPs), was named a winner for customer satisfaction in the 2020 American Business Awards and is one of Inc. Magazine’s Best Workplaces for 2020. For more information, visit http://www.cloudticity.com.

Media Contact:

Sterling Communications

Michelle Denny

+1 (408) 335-7331

cloudticity@sterlingpr.com

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MELVILLE, N.Y. (PRWEB)
August 10, 2020

PrestigePEO, a leading professional employer organization (PEO) that partners with small and mid-sized businesses throughout the United States to deliver full-service HR solutions, is excited to announce a new partnership with ExpensePath, enabling clients to offer a fully digital expense reporting and payroll experience to their employees – from request to reimbursement.

ExpensePath seamlessly integrates expense reporting and payroll, reducing administrative workloads and simplifying operations for your employees. With ExpensePath, employees simply enter their spending details online and submit for approval. Managers and finance departments can then quickly review and approve, and with just one click, export data to initiate reimbursement via payroll. The system is custom configured to meet the needs of each unique business.

ExpensePath goes beyond payroll to enable valuable process improvements. Features like automated violation tracking and customized trends and spend data reports can help SMBs gain control of costs and implement smarter spending policies. It also brings efficiency to time tracking, employee benefits, and other HR functions.

Employees at SMBs often spend so much of their time on burdensome, repetitive tasks that can easily be automated with the right technology platforms. The powerful combination of ExpensePath and PrestigePEO increases efficiency through each step of expense reporting and payroll processing, freeing up employee time and empowering them to focus on goals that truly drive business growth.

PrestigePEO is dedicated to continuously improving critical HR functions like payroll, employee benefits, legal compliance, and more for our clients. Contact PrestigePEO today to learn more about ExpensePath and all of our service offerings.

About PrestigePEO

PrestigePEO, incorporated as Prestige Employee Administrators Inc., empowers small and mid-sized businesses to simplify HR by offering end-to-end support for employee benefits management, payroll administration, workers’ compliance, HR guidance, and more. Merging the power of industry-leading customer service with innovative technology options, PrestigePEO delivers a full spectrum of HR services and solutions to help SMBs lower employee benefit costs, reduce administrative workloads, and manage critical HR functions. PrestigePEO is among only 1% of PEOs that are ESAC-accredited, Workers Comp Risk Management (CI)-certified, and classified as a Certified Professional Employer Organization (CPEO) by the IRS – demonstrating financial stability and strict adherence with a diverse range of regulatory and security standards. Headquartered in Melville, NY, PrestigePEO is licensed to support SMBs nationwide and proud to serve long-standing clients across the tri-state area.

Learn more at http://www.prestigepeo.com.

About ExpensePath

Launched in 2010, ExpensePath was founded to bring a simple solution for expense reporting to small- and mid-sized companies. Headquartered San Francisco, the company was founded by Vik Agrawal and Andrew Kothen to deliver a solution that delivered the same level of features as enterprise solutions but with an ease of use, level of support and pricepoint needed by smaller organizations. For more information, visit http://www.expensepath.com.

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