Patient studies with the assay have shown that CMMC counts correlate with clinical measures of disease burden, including percentage of bone marrow plasma cells, serum M protein, and International Staging System stage.

TORONTO (PRWEB)
November 06, 2020

Multiple myeloma is the second most prevalent hematological cancer in the United States, with approximately 30,000 new cases a year. At present, the disease remains incurable with a 5-year survival rate of 51%. To aid in the understanding of the biology of multiple myeloma and monitor clinical progression of the disease, a novel assay was developed using the CELLSEARCH® system to isolate and enumerate circulating multiple myeloma cells (CMMC) from peripheral blood.

Patient studies with the assay have shown that CMMC counts correlate with clinical measures of disease burden, including percentage of bone marrow plasma cells, serum M protein, and International Staging System stage. Patients with CMMC counts ≧ 100 in 4 mL blood during remission had worse progression-free survival compared with patients who had less than 100. Studies looking at the precursor disease state, smoldering multiple myeloma (SMM) showed that higher patient CMMC counts were associated with higher-risk myeloma states. This demonstrates the power of enumerating CMMC as a potential marker for disease progression and stage in a minimally-invasive assay.

Join Dr. Irene Ghobrial, M.D., DFCI, Director, Clinical Investigator Research Program at Dana-Farber Cancer Institute; Steven Gross, Head of Assay Development, Menarini Silicon Biosystems; and Sara Lazaro, Head of Clinical Lab Operations and Services, Menarini Silicon Biosystems in a live webinar on Friday, November 20, 2020 at 11am EST (4pm GMT/UK).

For more information, or to register for this event, visit Developing a Novel Assay for Circulating Multiple Myeloma Cells Using the CELLSEARCH Platform.

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