The speaker will present various physicochemical characterization studies, including mass spectroscopy, liquid chromatography, XPS and electron microscopy to validate successful synthesis and bioconjugation onto 2D and 3D substrates.
TORONTO (PRWEB)
December 05, 2022
A peptide nucleic acid (PNA) is a synthetic pseudo-peptide oligomer, analogous to a natural oligonucleotide, but in which the sugar-phosphate backbone is replaced with a polyamide backbone. Owing largely to their neutral and non-natural backbone, PNAs offer higher melting temperatures, greater sequence specificity as well as significantly enhanced duplex stability and chemical stability when compared to their natural counterparts. Due to these unique physicochemical properties, they have been widely investigated as powerful biomolecular tools, including molecular hybridization probes and antigene agents in diagnostic and therapeutic applications.
In this webinar, the featured speakers will demonstrate the rational design of bespoke peptide nucleic acid conjugates for translational applications, namely microRNA detection and antisense microRNA-based therapeutics. One example will explore ‘clickable’ PNA probes for the biofunctionalization of 2D materials enabling ultrasensitive electrochemical detection of microRNA. Another example will demonstrate how PNA probes can be tailored to enable UV-triggered and highly efficient bioconjugation within graphically-encoded hydrogel microparticles for multiplexed detection of microRNA.
In addition, the speaker will introduce the design and preparation of cell penetrating peptide (CPP)-conjugated PNAs for carrier-free delivery of anti-microRNA therapeutic agents into target cells. All examples will use probes that have been synthesized using solid phase peptide synthesis strategies with Fmoc chemistry on the Purepep Chorus automated synthesizer.
The speaker will present various physicochemical characterization studies, including mass spectroscopy, liquid chromatography, XPS and electron microscopy to validate successful synthesis and bioconjugation onto 2D and 3D substrates. Ultimately, this webinar will establish the immense potential of PNA-based technologies in cancer diagnosis and therapy through exploiting rational design and robust chemistries.
Register to learn more about the rational design of peptide nucleic acid conjugates for biomedical applications.
Join Dr. Dana Alsulaiman, Assistant Professor of Material Science and Bioengineering, King Abdullah University of Science and Technology (KAUST), for the live webinar on Thursday, December 15, 2022, at 9am EDT (3pm CEST).
For more information, or to register for this event, visit Rational Design of Peptide Nucleic Acid Conjugates for Biomedical Applications.
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