OmegaTOF
The OmegaTOF offers enhanced sample throughput, ease of use, low maintenance and a small footprint, making it ideal for all laboratories. Moreover, its quiet operation at
COLUMBIA, Md. (PRWEB)
April 04, 2022
Shimadzu Scientific Instruments, in collaboration with CovalX Instruments Inc., introduces the OmegaTOF benchtop high mass matrix-assisted laser desorption ionization–time-of-flight (MALDI-TOF) mass spectrometer. The OmegaTOF system couples Shimadzu’s benchtop MALDI-TOF instrument platform (MALDI-8020) with established technology for high mass detection from CovalX. The result is a user-friendly, compact platform that extends benchtop MALDI-TOF analysis to a mass range of 1.5 MegaDalton.
The high mass detection capabilities of the OmegaTOF allow the highest sensitivity for analyzing large biomolecules, protein interactions, peptides, oligonucleotides and polymers. This allows access to a full range of applications already developed and optimized by CovalX technologies, most notably characterizing monoclonal antibodies, such as IgG, IgA and IgM. Crosslinking chemistries developed by CovalX enable the OmegaTOF to measure intact protein interactions directly, providing insight into protein aggregation, mAb-antigen interactions, protein complex stoichiometry or ligand association-dissociation measurements.
The OmegaTOF offers enhanced sample throughput, ease of use, low maintenance and a small footprint, making it ideal for all laboratories. Moreover, its quiet operation at less than 55 dB expands use beyond the conventional laboratory setting.
For higher measurement speed, the OmegaTOF utilizes a 200 Hz solid-state 355 nm laser featuring a class-leading two billion shots per lifetime. It also offers a fast sample introduction using a load-lock chamber and quick sample stage movement.
The OmegaTOF platform features all of the latest technologies of the Shimadzu MALDI-8020 platform, including an integrated barcode reader, patented TrueClean™ source cleaning and WideBore™ ion optics technologies. The patented WideBore™ technology significantly reduces contamination from desorbed MALDI samples. The near-normal (on-axis) incidence of the MALDI laser beam and the camera view produce outstanding efficiency of the MALDI source and high-quality sample images. The TrueClean™ in-vacuum technology offers a UV laser-based source cleaning which extends the robustness of the OmegaTOF by self-cleaning the ion optics without breaking vacuum or removing the ion optics.
OmegaTOF data can be directly imported into the latest versions of CovalX ComplexTracker software for protein interaction analysis. Tailored MALDI Solutions acquisition software features data security for regulatory compliance facilitated with password-controlled user login, encrypted data and user traceability.
About CovalX
CovalX Instruments Incorporated is a fully owned subsidiary of CovalX AG. CovalX AG was founded in 2005 and has become a leading provider of technology and services in the field of High-Mass MALDI analysis of proteins and protein interactions. With support offices in Europe and North America, CovalX is a global company offering leading products and services for major pharmaceutical companies as well as academic laboratories. CovalX is developing innovative analysis solutions for the characterization of therapeutic proteins and protein interactions for the life science industry.
About Shimadzu Scientific Instruments Inc.
Shimadzu Scientific Instruments (SSI) is the North American subsidiary of Shimadzu Corporation’s Analytical and Measuring Division. Headquartered in Columbia, Maryland, SSI offers a comprehensive portfolio of analytical and testing solutions for a broad range of applications in science and industry. SSI maintains a network of ten regional offices strategically located across the United States, with experienced technical specialists, service providers and sales engineers situated throughout the country. In addition, SSI operates a Solution Center, designed to enable applications development, and an Innovation Center that houses a team of scientists whose goal is to develop close collaborations with universities, government agencies and industry centers.
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