Understanding the advantages and limitations of these approaches is critical for which technique is suitable for the target and gives the highest likelihood for achieving drug discovery goals.
TORONTO (PRWEB)
September 16, 2021
Affinity selection mass spectrometry (ASMS) has emerged as an attractive screening strategy for challenging protein and oligonucleotide targets, particularly those that do not exhibit functional activity. The general ASMS strategy encompasses incubating the target with a single or pool of small molecules, isolating the target-small molecule complex and then detecting the binding molecule using mass spectrometry.
This workflow has been applied with some variations using distinct methodologies and MS instrumentation. Understanding the advantages and limitations of these approaches is critical for which technique is suitable for the target and gives the highest likelihood for achieving drug discovery goals.
Register for this webinar to hear a discussion of key aspects to consider for maximizing opportunities to integrate a successful ASMS assay for drug discovery, including the small molecule library, the specific ASMS methodology and converting ASMS hits into promising leads. The webinar will highlight a recently described novel ASMS approach that combines surface chemistry with matrix assisted laser desorption ionization (MALDI) MS and the opportunities it affords for screening virtually any target.
Join Zack Gurard-Levin, Ph.D., Chief Scientific Officer, SAMDI Tech, for the live webinar on Tuesday, October 5, 2021 at 1pm EDT (10am PDT).
For more information, or to register for this event, visit Integrating Affinity Selection Mass Spectrometry (ASMS) Into a Drug Discovery Workflow.
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