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Immunophenotyping of T-cell Receptor and B-cell Receptor Clonotypes, Upcoming Webinar Hosted by Xtalks

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Register for this webinar to see data showing how combined TCR/BCR clonotype analysis combined with targeted expression profiling of immune cells can be applied for large-scale discovery of novel cell typing and activation biomarkers in several immune-response model systems.


TORONTO (PRWEB)

T-cell receptor (TCR) and B-cell receptor (BCR) repertoire profiling holds great potential for understanding the disease mechanisms and development of new therapeutics for infectious disease, auto-immunity and immuno-oncology applications. However, this potential could be greatly improved by combining information about receptor clonotypes with immunophenotypes of T and B cells. To facilitate these studies, we developed a novel technology for combined profiling of all human TCR and BCR variable regions and phenotypic characterization of immune cells in bulk and at the single-cell level in peripheral blood mononuclear cells (PBMC) and immune cell fraction samples.

The developed TCR/BCR Immunophenotyping method involves multiplex RT-PCR amplification and sequencing of complementarity-determining regions (CDR) of TCR and BCR genes and a set of the most informative T- and B-cell phenotyping genes. Bioinformatics analysis of NGS data allows for the profiling of TCR/BCR clonotypes, as well as identifying major immune cell subtypes and their activation status.

Register for this webinar to see data showing how combined TCR/BCR clonotype analysis combined with targeted expression profiling of immune cells can be applied for large-scale discovery of novel cell typing and activation biomarkers in several immune-response model systems. Preliminary studies demonstrate the assay has unparalleled throughput, sensitivity and improved cost-effectiveness for high-throughput immunity biomarker discovery applications.

Join Cellecta, Inc.’s President and Chief Scientific Officer Alex Chenchik, and Chief Operating Officer, Paul Diehl, Ph.D., for a live webinar on Friday, September 17, 2021 at 11am EDT (4pm BST/UK).

For more information, or to register for this event, visit Immunophenotyping of T-cell Receptor and B-cell Receptor Clonotypes.

ABOUT XTALKS

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To learn more about Xtalks visit http://xtalks.com

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