The presenters will outline critical considerations in the application of preclinical stage instruments into industry clinical trials, including those that become important as studies are longer in duration and are conducted across various regions of the world.
TORONTO (PRWEB)
October 23, 2019
Preclinical Alzheimer’s disease (AD) is classified in individuals who show abnormal levels of amyloid, tau or neurodegenerative biomarkers but who do not meet any clinical criteria for dementia or mild cognitive impairment. Current estimates indicate that this preclinical AD stage can last for more than 10 years and so it provides a unique opportunity to understand the clinical-pathological sequelae of very early AD. This information can be used to develop and implement therapeutic strategies that can slow or even halt these processes, so as to forestall the development of symptoms.
Clinical trials designed to study interventions at the preclinical AD stage are using fit-for-purpose clinical outcome assessments that have high validity and reliability for the detection of cognitive change at this early stage of the illness. This has led to the development of novel cognitive, functional and patient-reported outcomes specifically designed for early-stage disease. These assessments have novel requirements for their delivery that differ markedly from the conventional instruments used in trials conducted for mild cognitive impairment and dementia.
Learn how to address potential challenges associated with preclinical AD assessments by joining experts from Cogstate, a leading science and technology solutions provider in a live webinar on Thursday, November 7, 2019 at 11am EST (4pm GMT/UK).
The presenters will outline critical considerations in the application of preclinical stage instruments into industry clinical trials, including those that become important as studies are longer in duration and are conducted across various regions of the world.
For more information or to register for this event, visit Clinical Outcome Assessments in Preclinical Alzheimer’s Disease: Considerations for Global Clinical Trials.
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