IRVINE, Calif. (PRWEB)
March 15, 2023

Regardless of whether the age-old myth of explorer Ponce de Leon searching for a Fountain of Youth is true, a new nutraceutical reaching the consumer market will mark a major milestone in the expedition towards improving the process of aging.

Researchers at Irvine, California-based Seragon Biosciences have developed a proprietary set of molecules that have been found to slow aging and issues that arise with aging. When integrated with a new controlled release technology, this new nutraceutical RESTORIN can attack the aging process at the cellular level.

“There are many studies that point to these molecules having a positive impact on aging and aging-related health conditions, but, so far, no one has been able to combine them at an optimal ratio to achieve a synergistic effect,” said David Brown, Ph.D., a senior scientist at Seragon who helped develop RESTORIN. “We’ve been able to develop advanced forms of these molecules and a series of complex combinations to combat aging, using the best science we have. This is truly a game-changer.”

Scientists at Seragon integrated three areas of advanced anti-aging research to develop RESTORIN: A NAD+ complex made of proprietary forms of nicotinamide adenine dinucleotide (NAD+) precursors; A SSA complex consisting of multiple senolytic agents and a group of sirtuin-activating compounds (STACs); and a group of B vitamin compounds that provide additional support to healthy aging of the brain and the nervous system.

Based on research conducted at Harvard University, Mayo Clinic, and Scripps Research, which licensed a series of core patents to Seragon, senolytic agents used in RESTORIN, can reduce senescent cells – growth-arrested cells that build up as we age and hinder tissue repair – while not affecting healthy, regular cells. Studies in mice have shown that supplementing these senolytic agents increased their remaining lifespan by as high as 60 percent.

Senescent cell accumulation is tied to many age-related issues. As we age, our cells accumulate DNA damage resulting from environmental toxins, imprecise DNA replication, mitochondrial dysfunction, and inflammation. These factors ultimately lead to the formation of new senescent cells, which continuously sprout throughout the body and tarnish vital networks that trigger organ deterioration and systemic inflammation.

What makes senolytics unique is their ability to selectively target senescent cells, thus alleviating senescent cell burden. Rodent studies have demonstrated that senolytics can enhance muscle regeneration by limiting senescent cell burden in muscle tissue. Other studies have shown that using senolytics to reduce oxidative stress and cellular senescence in the brain can improve brain health. Through a series of collaborations with Harvard, Mayo, Scripps, and other industry partners, Seragon was able to significantly enhance the bioavailability of RESTORIN’s senolytic agents, making them suitable for oral delivery.

Another key component of RESTORIN is the NAD+ precursor complex. NAD+ is an essential coenzyme in the body. Other than water itself, NAD+ is the most abundant molecule in the human body. NAD+ is a key component in our metabolic processes and immune systems and is responsible for repairing DNA damage that all of us suffer due to common and unavoidable exposure to pollutants, radiation, and more. NAD+ is also key to the function of sirtuins – guardian proteins in the body that manage cell health and are linked to longevity. In fact, as we age, our levels of NAD+ drop. And, without NAD+, we’d all be dead.

While NAD+ isn’t a new discovery (it was discovered in 1906), scientists have long tried to figure out how to supplement it. The body cannot simply absorb more NAD+ itself, so scientists have focused on how to get the body to create more of it. That’s where NAD+ precursors come in. Studies have shown they have a distinct ability to increase NAD+ production. Seragon has made advancements to effectively deliver these precursors into the body, maximizing the potential for NAD+ repletion.

In recent years, the effective delivery of NAD+ precursors has been deemed the “holy grail” of anti-aging research. To tackle this challenge, RESTORIN’s development team created proprietary, more stable forms of NAD+ precursors. They then coupled them with Seragon’s SERC™ controlled release technology that utilizes hydrophilic and lipophilic vehicles and a pH-responsive enteric delivery system to enhance cellular NAD+ levels. Researchers at Seragon concluded that these new forms of NAD+ precursor complexes, when combined with the other molecules in RESTORIN, will effectively attack aging and issues linked to aging from several angles.

“In the field of aging, a critical issue to resolve is how to deliver NAD+ precursors in a way that best boosts cellular NAD+ to achieve healthier aging,” said Dr. Brown. “We believe that RESTORIN has achieved best-in-class performance in this regard, which is truly a breakthrough. Especially when you consider recent studies showing an increase in NAD+ can even make immunotherapies against cancer more effective, it’s very exciting to be a part of this development.”

“It’s very thrilling to see aging research advancing ways to help people age slower, better, and healthier,” he added.

RESTORIN is available to consumers exclusively through its official website, http://www.restorin.com.

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